PURCHASE OF CUTTING EDGE CANCER CELL ANALYSIS EQUIPMENT DRAWS FUNDS FROM MULTIPLE HMCRT SUPPORTERS AND THEIR EFFORTS - RECORD FUNDRAISING YEAR FOR HMCRT

Theo Brun's Final Approach to Norfolk Culmination of a Great Year of Fundraising Ventures from Many of Harry's Former Oarsmen.

The HMCRT's newest Nanostring cancer technology equipment purchase is made possible through funds drawn from multiple efforts from our supporters in recent months, including over £10,000 in donations to Theo Brun's transcontinental bike ride, over £2,500 from Nick Norgate's running, over £1,600 via Alex Sant's Middle Eastern marathoning and most recently funds from Jamie Hewitson's and Cameron Duncan's fundraising efforts. Theo's example has prompted many others to rally and dig deep both athletically and financially - many many THANKS TO YOU ALL!

This new Nanostring technology is being employed by Enzo's laboratory team at Oxford who have demonstrated that tumour cells can hamper the ability of the immune system to fight cancer. In particular, most recent results have shown that one of the mechanisms used by cancer cells to suppress tumour specific immunity is related to their ability to modify the expression of genes. Factors secreted by cancer cells can activate proteins, called epigenetic regulators, which can switch on and off different parts of the DNA in immune cells, turning cells that should fight against tumours into cells that suppress the immune response, hence facilitating cancer growth. Expression of genes encoding these "regulators" can be monitored by new NanoString technology equipment. Enzo's lab will use this technology to analyse more than 100 epigenetic regulators to see how they correlates with the failure of the immune system to fight cancer. This analysis may lead to the identification of potential targets for the development of drugs capable of improving the treatment of cancer. Cutting edge stuff; just what Harry Mahon ordered.